Research Center for Translational Medicine
East Hospital
No. 150 Jimo Road
Shanghai 200120

YU Zuoren, Ph.D
Advanced Center for Translational Medicine
Shanghai East Hospital and School of Medicine
Tongji University
Shanghai 2000120, China


Yu Zuoren obtained his Ph.D. from Peking Union Medical College and the Chinese Academy of Medical Sciences in Beijing in 2003.  He then pursued postdoctoral studies at the University of Pennsylvania School of Medicine (2004-2006) and the Kimmel Cancer Center of Thomas Jefferson University (2006-2009) in Philadelphia.  He remained at the latter Institution as a Research Assistant Professor until 2012.  Yu’s research focuses on the role of microRNAs in cancer, in particular miR17/20, which he linked to inhibition cyclin D1 and suppression of an heterotypic signaling network driving tumor invasion and metastasis in breast cancer.  Yu’s current research focuses on the role of microRNAs in the acquisition of stem cell traits, such as drug resistance and metastatic capacity, by breast cancer cells.


Selected publications:

  1.  Yu Z#, Xu Z, Di Sante G, Wright J, Wang M, Li Y, Zhao Q, Gutman E, Wang G, Ju X, Li T, Xiang Z, Wang C, Yang X, Yang X, and Pestell R#. miR‐17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget 5:1083-90 (2014)
  2.  Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, and Pestell RG. Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat. Commun. 4:2812 (2013).
  3.  Yu Z, Willmarth NE, Zhou J, Katiyar S, Wang M, Liu Y, McCue P, Quong AA, Lisanti MP, and Pestell RG. microRNA 17/20 mediates cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc. Natl. Acad. Sci. USA 107:8231-6 (2010).
  4.  Genander M, Halford MM, Martling A, Xu N-J, Yu Z, Greicius G, Chumley MJ, Zdunek S, Holm T, Pettersson S, Pestell RG, Henkemeyer M, and Frisén J. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 139:679-92 (2009).
  5.  Yu Z, Wang C, Wang M, Li Z, Casimiro MC, Liu M, Wu K, Whittle J, Ju X, Hyslop T, McCue P, and Pestell RG. A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J. Cell Biol. 182:509-17 (2008).


# co-corresponding author

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