Research Center for Translational Medicine
East Hospital
No. 150 Jimo Road
Shanghai 200120
China

GAO Shaorong, Ph.D.
Professor and Dean
School of Life Sciences and Technology
Tongji University
Shanghai, 200092 China

 

Gao Shaorong received a Doctoral degree in Reproductive Biology from the Institute of Zoology, Chinese Academy of Sciences.  He then performed postdoctoral studies in the UK and USA, focusing on somatic cell reprogramming.  He returned to China in 2005 and worked as an investigator in the National Institute of Biological Sciences, Beijing. In 2013, he moved to Tongji University.  Gao’s group is studying the molecular mechanisms underlying somatic cell reprogramming mediated by somatic cell nuclear transfer (SCNT) and defined transcription factors.  The research in his lab has demonstrated that induced pluripotent stem (iPS) cells reprogrammed directly from differentiated somatic cells by defined transcription factors can produce viable all-iPS mice through tetraploid complementation.

 

Selected publications:

  1.  Gao S, Zheng C, Chang G, Liu W, Kou X, Tan K, Tao L, Xu K, Wang H, Cai J, Tian J, and Gao S. Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells. Nat Commun. 18:6318 (2015).
  2.  Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z, and Gao S. Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells. Cell Stem Cell 14:27-39 (2014).
  3.  Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhan Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, and Gao S. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 12:453-69 (2013) [Cover Story; Previewed by Cell Stem Cell; Selected as Best of 2013 by Cell Stem Cell].
  4.  Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S#, and Zhu B#. (2012) Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 337:971-5 (2012).
  5.  Kang L, Wang J, Zhang Y, Kou Z, and Gao S. (2009) iPS cells can support full term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 5:135-138 (2009) [Highlighted by Nature, Nature China; “Must Read” by Faculty 1000; Featured in TIME Magazine, Washington Post, Wall Street Journal, Xinhua News, USA Today, The Scientist, The Economist, ABC News, The Independent, and Scientific American].

 

# co-corresponding author

Home Institution website:  http://life.tongji.edu.cn/Show.aspx?info_id=1142&info_lb=298&flag=98
E mail: gaoshaorong@tongji.edu.cn