Research Center for Translational Medicine
East Hospital
Tongji University
Shanghai 200092

FEI Jian, Ph.D,
School of Life Sciences and Technology
Tongji University, Shanghai, 200092 China


Fei Jian has pioneered the use of genetic methods in model organisms to study the role of transcription factors and cell surface and secreted protein in development, cancer, and neurodegeneration.  His research group routinely employs mice, zebrafish, and C. elegans to unravel the mechanisms underlying complex biological and pathological processes with the ultimate goal of identifying new therapies for human disease.  Fei’s group is currently designing new elegant techniques for gene editing and brings to the MRI his outstanding expertise in gene editing in mice and other models of tumor progression and metastasis.


Selected publications:

  1.  Sun Y, Sheng Z, Ma C, Tang K, Zhu R, Wu Z, Shen R, Feng J, Wu D, Huang D, Huang D, Fei J, Liu Q, and Cao Z. Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer. Nat. Commun. 6:8481 (2015).
  2.  Ma M, Wu W, Li Q, Li J, Sheng Z, Shi J, Zhang M, Yang H, Wang Z, Sun R, and Fei J. N-myc is a key switch regulating the proliferation cycle of postnatal cerebellar granule cell progenitors. Sci Rep. 5:12740 (2015).
  3.  Ying Y, Yang X, Zhao K, Mao J, Kuang Y, Wang Z, Sun R, and Fei J. The Krüppel-associated box repressor domain induces reversible and irreversible regulation of endogenous mouse genes by mediating different chromatin states. Nucleic Acids Res. 43:1549-61 (2015).
  4.  Liu H, Wise SG, Rnjak-Kovacina J, Kaplan DL, Bilek MM, Weiss AS, Fei J, and Bao S. Biocompatibility of silk-tropoelastin protein polymers. Biomaterials 19:5138-47 (2014).
  5.  Sun R, Zhao K, Shen R, Cai L, Yang X, Kuang Y, Mao J, Huang F, Wang Z, and Fei J. Inducible and reversible regulation of endogenous gene in mouse. Nucleic Acids Res. 40:e166 (2012).


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