Research Center for Translational Medicine
East Hospital
No. 150 Jimo Road
Shanghai 200120

JIANG Cizhong, Ph.D.
Shanghai Key Laboratory of Signaling and Disease Research
Collaborative Innovation Center for Brain Science
School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
BRIEF HISTORY….  Cizhong Jiang obtained his Ph.D. degree from Iowa State University in 2004. After performing postdoctoral studies at Cold Spring Harbor Laboratory (2004-2005), Virginia Commonwealth University (2005-2007), and Pensylvania State University (2007-2009), he established his laboratory at Tongji University, Shanghai in 2009. Cizhong Jiang uses biochemical and computational methods to study the role of chromatin remodeling, nucleosome positioning and histone modifications in tumor progression and metastasis with a special emphasis on the interaction between driver oncogenic mutations and chromatin remodeling enzymes and/or histone chaperones. In addition, Jiang’s group is examining cancer-related ‘omics’ and clinical datasets from TCGA and ICGC projects to identify new molecular markers of disease progression.  Jiang brings to the MRI his expertise in epigenetics and bioinformatics analysis of big data.
Selected publications:

  1.  Chen J, Chen X, Li M, Liu X, Gao Y, Kou X, Zhao Y, Zheng W, Zhang X, Huo Y, Chen C, Wu Y, Wang H, Jiang C#, Gao S#. Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming. Cell Rep. 14:1540-54. (2016).
  2.  Shen J, Jia W, Yu Y, Chen J, Cao X, Du Y, Zhang X, Zhu S, Chen W, Xi J, Wei T, Wang G, Yuan D, Duan T, Jiang C#, and Kang J#. Pwp1 Is required for the differentiation potential of mouse embryonic stem cells through regulation of Stat3 signaling. Stem Cells 33:661-73 (2015).
  3.  Tao Y, Zheng W, Jiang Y, Ding G, Hou X, Tang Y, Li Y, Gao S, Chang G, Zhang X, Liu W, Kou X, Wang H, Jiang C#, and Gao S# (2014) Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers. BMC Biol. 12:109 (2014).
  4.  Shi J, Zheng M, Ye Y, Li M, Chen X, Hu X, Sun J, Zhang X, and Jiang C. (2014) Drosophila Brahma complex remodels nucleosome organizations in multiple aspects. Nucleic Acids Res. 42:9730-9 (2014).
  5.  Jiang C and Pugh BF. (2009) Nucleosome positioning and gene regulation: advances through genomics. Nat. Rev. Genetics 10:161-72 (2009).

# co-corresponding author
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