Research Center for Translational Medicine
East Hospital
Tongji University
Shanghai 200092

XIE Xin, Ph.D.
Professor and Deputy Director,
National Center for Drug Screening,
Shanghai Institute of Materia Medica,
Chinese Academy of Sciences
Shanghai 201203, China


Xie Xin received her B.S. in Chemistry from Peking University in 1996, and her Ph.D. in Neurosciences from the University of Medicine and Dentistry of New Jersey in 2002. Xie’s team is pursuing several drug discovery projects related to G protein-coupled receptors, including target validation, assay development, high-throughput screening and preliminary in vivo pharmacology. While her basic research laboratory focuses on autoimmune and neurodegenerative diseases, the efforts of her team include the identification of small molecules that can induce somatic cell reprogramming and transdifferentiation.  Xie’s team brings to the MRI outstanding expertise in drug development and an extensive collection of compound libraries, including a very large collection of chinese traditional medicine compounds.


Selected publications:

  1.  Fu Y, Huang C, Xu X, Gu H, Ye Y, Jiang C, Qiu Z, and Xie X. Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Res. 25:1013-24 (2015).
  2.  Zhang S, Ma Y, Li J, Yu B#, and Xie X#. Molecular matchmaking between the popular ‘weight loss’ herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorders. Proc. Natl. Acad. Sci. USA 111:14571-6 (2014).
  3.  Chen G, Xu X, Zhang L, Fu Y, Wang M, Gu H, and Xie X. Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cells self-renewal and somatic cell reprogramming. Cell Res. 24:1121-36 (2014).
  4.  Wang Q, Xu X, Li J, Liu J, Gu H, Zhang R, Chen J, Kuang Y, Fei J, Jiang C, Wang P, Pei D, Ding S, and Xie X. Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res. 21:1424-35 (2011).
  5.  He X, Fang L, Wang J, Yi Y, Zhang S, and Xie X. Bryostatin-5 blocks stromal cell-derived factor-1-induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Res. 68:8678-86 (2008).

# co-corresponding author

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