MAO Zhiyong, Ph.D
School of Life Sciences and Technology
Shanghai, 200092 China
BRIEF HISTORY…. Defects in DNA repair, such as those arising from mutations in BRCA1, can initiate tumor development. Mao’s laboratory uses easy-to-quantify and real-time reporter cassettes to measure the efficiency of two pathways of DNA double strand break repair: nonhomologous end joining (NHEJ) and homologous recombination (HR). Through its studies, the group aims to understand the regulatory mechanisms of NHEJ and HR during tumorigenesis, and to eventually develop novel ways to diagnose and treat cancer.
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